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FDA Approves Juvisync for Diabetes, High Cholesterol
The Food and Drug Administration on Oct. 7 announced the approval of a combination pill containing fixed doses of sitagliptin and simvastatin for people in whom treatment with both drugs is indicated.
The combination product, which will be marketed as Juvisync, is the first product that combines in a single tablet a drug approved for treating type 2 diabetes with a cholesterol-lowering drug, according to an agency statement announcing the approval.
Sitagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor approved for use in combination with diet and exercise to improve glycemic control in adults with type 2 diabetes; it is marketed as Januvia (and as Janumet in combination with metformin). Simvastatin is an HMG-CoA reductase inhibitor approved for use with diet and exercise to lower low-density lipoprotein cholesterol and is marketed as Zocor and is available in generic formulations (and in combination with niacin and with ezetimibe).
Approval of Juvisync is based on the "substantial experience" with both drugs separately, "and the ability of the single tablet to deliver similar amounts of the drugs to the bloodstream as when sitagliptin and simvastatin are taken separately," according to the statement, which describes Juvisync as a "convenience combination" that should only be prescribed "when it is appropriate for a patient to be placed on both of these drugs."
"To ensure safe and effective use of this product, tablets containing different doses of sitagliptin and simvastatin in fixed-dose combination have been developed to meet the different needs of individual patients," Dr. Mary H. Parks, director of the Division of Metabolism and Endocrinology Products in the FDA’s Center for Drug Evaluation and Research said in the statement.
The approved dosage strengths of the sitagliptin/simvastatin combination are 100 mg/10 mg, 100 mg/20 mg, and 100 mg/40 mg, all of which are taken as a single dose in the evening, according to the prescribing information.
The manufacturer has committed to developing combined tablets containing the 50 mg sitagliptin dose, with 10 mg, 20 mg and 40 mg of simvastatin, but until these are available, patients who need the 50-mg dose of sitagliptin should be prescribed the single-ingredient tablet. There are no plans to develop a combination tablet with the 25-mg sitagliptin dose, which is not used very much, or with the 80-mg dose of simvastatin, because of recent restrictions on the use of this dose because it is associated with an increased risk of muscle toxicity, the statement said.
The statement says that the agency has recently become aware of the potential for statins to increase serum glucose levels in patients with type 2 diabetes, although the risk "appears very small and is outweighed by the benefits of statins for reducing heart disease in diabetes." To assess this risk further, the FDA is requiring that the manufacturer conduct a postmarketing clinical study. The FDA’s approval letter for Juvisync says that the trial should be a randomized, double-blind, active-controlled study that compares the effect of sitagliptin and simvastatin fixed-dose combination with sitagliptin on glycemic control in type 2 diabetic patients on background metformin therapy.
Juvisync is manufactured by MSD International GmbH Clonmel Co., based in Tipperary, Ireland.
The Food and Drug Administration on Oct. 7 announced the approval of a combination pill containing fixed doses of sitagliptin and simvastatin for people in whom treatment with both drugs is indicated.
The combination product, which will be marketed as Juvisync, is the first product that combines in a single tablet a drug approved for treating type 2 diabetes with a cholesterol-lowering drug, according to an agency statement announcing the approval.
Sitagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor approved for use in combination with diet and exercise to improve glycemic control in adults with type 2 diabetes; it is marketed as Januvia (and as Janumet in combination with metformin). Simvastatin is an HMG-CoA reductase inhibitor approved for use with diet and exercise to lower low-density lipoprotein cholesterol and is marketed as Zocor and is available in generic formulations (and in combination with niacin and with ezetimibe).
Approval of Juvisync is based on the "substantial experience" with both drugs separately, "and the ability of the single tablet to deliver similar amounts of the drugs to the bloodstream as when sitagliptin and simvastatin are taken separately," according to the statement, which describes Juvisync as a "convenience combination" that should only be prescribed "when it is appropriate for a patient to be placed on both of these drugs."
"To ensure safe and effective use of this product, tablets containing different doses of sitagliptin and simvastatin in fixed-dose combination have been developed to meet the different needs of individual patients," Dr. Mary H. Parks, director of the Division of Metabolism and Endocrinology Products in the FDA’s Center for Drug Evaluation and Research said in the statement.
The approved dosage strengths of the sitagliptin/simvastatin combination are 100 mg/10 mg, 100 mg/20 mg, and 100 mg/40 mg, all of which are taken as a single dose in the evening, according to the prescribing information.
The manufacturer has committed to developing combined tablets containing the 50 mg sitagliptin dose, with 10 mg, 20 mg and 40 mg of simvastatin, but until these are available, patients who need the 50-mg dose of sitagliptin should be prescribed the single-ingredient tablet. There are no plans to develop a combination tablet with the 25-mg sitagliptin dose, which is not used very much, or with the 80-mg dose of simvastatin, because of recent restrictions on the use of this dose because it is associated with an increased risk of muscle toxicity, the statement said.
The statement says that the agency has recently become aware of the potential for statins to increase serum glucose levels in patients with type 2 diabetes, although the risk "appears very small and is outweighed by the benefits of statins for reducing heart disease in diabetes." To assess this risk further, the FDA is requiring that the manufacturer conduct a postmarketing clinical study. The FDA’s approval letter for Juvisync says that the trial should be a randomized, double-blind, active-controlled study that compares the effect of sitagliptin and simvastatin fixed-dose combination with sitagliptin on glycemic control in type 2 diabetic patients on background metformin therapy.
Juvisync is manufactured by MSD International GmbH Clonmel Co., based in Tipperary, Ireland.
The Food and Drug Administration on Oct. 7 announced the approval of a combination pill containing fixed doses of sitagliptin and simvastatin for people in whom treatment with both drugs is indicated.
The combination product, which will be marketed as Juvisync, is the first product that combines in a single tablet a drug approved for treating type 2 diabetes with a cholesterol-lowering drug, according to an agency statement announcing the approval.
Sitagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor approved for use in combination with diet and exercise to improve glycemic control in adults with type 2 diabetes; it is marketed as Januvia (and as Janumet in combination with metformin). Simvastatin is an HMG-CoA reductase inhibitor approved for use with diet and exercise to lower low-density lipoprotein cholesterol and is marketed as Zocor and is available in generic formulations (and in combination with niacin and with ezetimibe).
Approval of Juvisync is based on the "substantial experience" with both drugs separately, "and the ability of the single tablet to deliver similar amounts of the drugs to the bloodstream as when sitagliptin and simvastatin are taken separately," according to the statement, which describes Juvisync as a "convenience combination" that should only be prescribed "when it is appropriate for a patient to be placed on both of these drugs."
"To ensure safe and effective use of this product, tablets containing different doses of sitagliptin and simvastatin in fixed-dose combination have been developed to meet the different needs of individual patients," Dr. Mary H. Parks, director of the Division of Metabolism and Endocrinology Products in the FDA’s Center for Drug Evaluation and Research said in the statement.
The approved dosage strengths of the sitagliptin/simvastatin combination are 100 mg/10 mg, 100 mg/20 mg, and 100 mg/40 mg, all of which are taken as a single dose in the evening, according to the prescribing information.
The manufacturer has committed to developing combined tablets containing the 50 mg sitagliptin dose, with 10 mg, 20 mg and 40 mg of simvastatin, but until these are available, patients who need the 50-mg dose of sitagliptin should be prescribed the single-ingredient tablet. There are no plans to develop a combination tablet with the 25-mg sitagliptin dose, which is not used very much, or with the 80-mg dose of simvastatin, because of recent restrictions on the use of this dose because it is associated with an increased risk of muscle toxicity, the statement said.
The statement says that the agency has recently become aware of the potential for statins to increase serum glucose levels in patients with type 2 diabetes, although the risk "appears very small and is outweighed by the benefits of statins for reducing heart disease in diabetes." To assess this risk further, the FDA is requiring that the manufacturer conduct a postmarketing clinical study. The FDA’s approval letter for Juvisync says that the trial should be a randomized, double-blind, active-controlled study that compares the effect of sitagliptin and simvastatin fixed-dose combination with sitagliptin on glycemic control in type 2 diabetic patients on background metformin therapy.
Juvisync is manufactured by MSD International GmbH Clonmel Co., based in Tipperary, Ireland.
Small Changes Count in Type 2 Diabetes Patients
LISBON – Even small changes in hemoglobin A1c and blood pressure could significantly reduce the risk of heart attack, stroke, and other cardiovascular complications in people with type 2 diabetes, according to the findings of a population-based observational study.
A 0.5% decrease in HbA1c and a 10 Hg/mm decrease in systolic blood pressure could avert 10% of such events over 5 years, Dr. Edith Heintjes said at the annual meeting of the European Society for the Study of Diabetes. Greater changes could reduce cardiovascular events by as much as 21%, said Dr. Heintjes of the PHARMO Institute for Drug Research, Utrecht, the Netherlands.
While her study on population attributable risk was albeit theoretical, it still adds weight to the emerging theory that small changes can make a big difference to the health of people with type 2 diabetes.
"Even when we examined only modest incremental reductions, which could be achieved in the clinical setting, we found the possibility of significant benefit," she said. Those patients with the greatest risk factors – elevated HbA1c, high blood pressure, and higher body mass index – stand to gain the most when they improve those factors, she said.
Dr. Heintjes’ analysis included 5,841 Dutch patients with a diagnosis of type 2 diabetes for at least 2 years. The patients were all taking some form of treatment – oral medications, insulin, or both – for at least 6 months to be included in the study. After examining both baseline data and 5-year outcomes, she was able to extrapolate how improvements in the three risk factors might impact the expected number of cardiovascular events.
Patient data were drawn from the PHARMO record linkage system, which includes community pharmaceutical dispensing information, laboratory information, national hospitalization information, and statistics from the Dutch national diabetes monitoring program.
Patients were treated with the aim of achieving the country’s national targets: an HbA1c of below 7%, a systolic blood pressure of 140 mmHg or lower, and a body mass index of 25 kg/m2 or less.
"Even when we examined only modest incremental reductions, we found the possibility of significant benefit."
At baseline, the patients’ average age was 66 years. The average HbA1c was 7%; systolic blood pressure 149 mmHg, and body mass index, 29.5 kg/m2. Most (92%) were taking only oral medications; the remainder was also taking insulin.
Some cardiovascular morbidity was already present in the group, including peripheral artery disease (0.5%), renal impairment (11%), neuropathy (51%), and retinopathy (7%). About half of the group (45%) had a family history of cardiovascular disease.
Dr. Heintjes divided the group according to the number of risk factors each patient exhibited. A quarter (24%) had just one elevated risk factor; 47% had two elevated risk factors, and 26% had elevations in all three risk factors.
A multivariable analysis allowed her to extrapolate that 796 cardiovascular events (heart attack, ischemic heart disease, stroke, and chronic heart failure) would occur if all of the patients were followed for 5 years.
If every patient in this population were able to correct each one of the risk factors to the national recommendations, she said, 687 events would occur – a 14% decrease. Correcting HbA1c and blood pressure accounted for this change, she said; changing BMI did nothing to increase the benefit.
Theoretically, she said, patients with the most risk factors would reap the greatest benefit. The 24% with one elevated risk factor would experience a 5% reduction in cardiovascular events, while those with all three elevated risk factors, upon correcting them, would see a 21% reduction.
Considering the group’s baseline measurements, correcting to national Dutch standards would mean an average HbA1c reduction of 0.8%, a 26-mmHg reduction in systolic blood pressure, and a weight loss of 16 kg (equivalent to a BMI decrease of 5.7 kg/m2). However, Dr. Heintjes said, it might not be realistic to expect such changes. Her second analysis explored the improvements that could arise from smaller changes: a 0.5% reduction in HbA1c, a 10-mmHg reduction in systolic blood pressure and a 10% reduction in total body weight (2.6 kg/m2 decrease in BMI).
"With this analysis, we saw in the overall population that 6% of the risk could be averted," she said. Among those in the subpopulation with three risk factors, applying the smaller changes could cut the number of events by 10%.
It’s not exactly clear how the results can change clinical practice, Dr. Heintjes acknowledged. "But this does allow us to understand how small changes can translate into bigger benefits for people with type 2 diabetes."
Dr. Heintjes reported having no conflicts of interest. Her employer, PHARMO, however, receives funding from numerous pharmaceutical companies, including Astra Zeneca, which sponsored the current study.
LISBON – Even small changes in hemoglobin A1c and blood pressure could significantly reduce the risk of heart attack, stroke, and other cardiovascular complications in people with type 2 diabetes, according to the findings of a population-based observational study.
A 0.5% decrease in HbA1c and a 10 Hg/mm decrease in systolic blood pressure could avert 10% of such events over 5 years, Dr. Edith Heintjes said at the annual meeting of the European Society for the Study of Diabetes. Greater changes could reduce cardiovascular events by as much as 21%, said Dr. Heintjes of the PHARMO Institute for Drug Research, Utrecht, the Netherlands.
While her study on population attributable risk was albeit theoretical, it still adds weight to the emerging theory that small changes can make a big difference to the health of people with type 2 diabetes.
"Even when we examined only modest incremental reductions, which could be achieved in the clinical setting, we found the possibility of significant benefit," she said. Those patients with the greatest risk factors – elevated HbA1c, high blood pressure, and higher body mass index – stand to gain the most when they improve those factors, she said.
Dr. Heintjes’ analysis included 5,841 Dutch patients with a diagnosis of type 2 diabetes for at least 2 years. The patients were all taking some form of treatment – oral medications, insulin, or both – for at least 6 months to be included in the study. After examining both baseline data and 5-year outcomes, she was able to extrapolate how improvements in the three risk factors might impact the expected number of cardiovascular events.
Patient data were drawn from the PHARMO record linkage system, which includes community pharmaceutical dispensing information, laboratory information, national hospitalization information, and statistics from the Dutch national diabetes monitoring program.
Patients were treated with the aim of achieving the country’s national targets: an HbA1c of below 7%, a systolic blood pressure of 140 mmHg or lower, and a body mass index of 25 kg/m2 or less.
"Even when we examined only modest incremental reductions, we found the possibility of significant benefit."
At baseline, the patients’ average age was 66 years. The average HbA1c was 7%; systolic blood pressure 149 mmHg, and body mass index, 29.5 kg/m2. Most (92%) were taking only oral medications; the remainder was also taking insulin.
Some cardiovascular morbidity was already present in the group, including peripheral artery disease (0.5%), renal impairment (11%), neuropathy (51%), and retinopathy (7%). About half of the group (45%) had a family history of cardiovascular disease.
Dr. Heintjes divided the group according to the number of risk factors each patient exhibited. A quarter (24%) had just one elevated risk factor; 47% had two elevated risk factors, and 26% had elevations in all three risk factors.
A multivariable analysis allowed her to extrapolate that 796 cardiovascular events (heart attack, ischemic heart disease, stroke, and chronic heart failure) would occur if all of the patients were followed for 5 years.
If every patient in this population were able to correct each one of the risk factors to the national recommendations, she said, 687 events would occur – a 14% decrease. Correcting HbA1c and blood pressure accounted for this change, she said; changing BMI did nothing to increase the benefit.
Theoretically, she said, patients with the most risk factors would reap the greatest benefit. The 24% with one elevated risk factor would experience a 5% reduction in cardiovascular events, while those with all three elevated risk factors, upon correcting them, would see a 21% reduction.
Considering the group’s baseline measurements, correcting to national Dutch standards would mean an average HbA1c reduction of 0.8%, a 26-mmHg reduction in systolic blood pressure, and a weight loss of 16 kg (equivalent to a BMI decrease of 5.7 kg/m2). However, Dr. Heintjes said, it might not be realistic to expect such changes. Her second analysis explored the improvements that could arise from smaller changes: a 0.5% reduction in HbA1c, a 10-mmHg reduction in systolic blood pressure and a 10% reduction in total body weight (2.6 kg/m2 decrease in BMI).
"With this analysis, we saw in the overall population that 6% of the risk could be averted," she said. Among those in the subpopulation with three risk factors, applying the smaller changes could cut the number of events by 10%.
It’s not exactly clear how the results can change clinical practice, Dr. Heintjes acknowledged. "But this does allow us to understand how small changes can translate into bigger benefits for people with type 2 diabetes."
Dr. Heintjes reported having no conflicts of interest. Her employer, PHARMO, however, receives funding from numerous pharmaceutical companies, including Astra Zeneca, which sponsored the current study.
LISBON – Even small changes in hemoglobin A1c and blood pressure could significantly reduce the risk of heart attack, stroke, and other cardiovascular complications in people with type 2 diabetes, according to the findings of a population-based observational study.
A 0.5% decrease in HbA1c and a 10 Hg/mm decrease in systolic blood pressure could avert 10% of such events over 5 years, Dr. Edith Heintjes said at the annual meeting of the European Society for the Study of Diabetes. Greater changes could reduce cardiovascular events by as much as 21%, said Dr. Heintjes of the PHARMO Institute for Drug Research, Utrecht, the Netherlands.
While her study on population attributable risk was albeit theoretical, it still adds weight to the emerging theory that small changes can make a big difference to the health of people with type 2 diabetes.
"Even when we examined only modest incremental reductions, which could be achieved in the clinical setting, we found the possibility of significant benefit," she said. Those patients with the greatest risk factors – elevated HbA1c, high blood pressure, and higher body mass index – stand to gain the most when they improve those factors, she said.
Dr. Heintjes’ analysis included 5,841 Dutch patients with a diagnosis of type 2 diabetes for at least 2 years. The patients were all taking some form of treatment – oral medications, insulin, or both – for at least 6 months to be included in the study. After examining both baseline data and 5-year outcomes, she was able to extrapolate how improvements in the three risk factors might impact the expected number of cardiovascular events.
Patient data were drawn from the PHARMO record linkage system, which includes community pharmaceutical dispensing information, laboratory information, national hospitalization information, and statistics from the Dutch national diabetes monitoring program.
Patients were treated with the aim of achieving the country’s national targets: an HbA1c of below 7%, a systolic blood pressure of 140 mmHg or lower, and a body mass index of 25 kg/m2 or less.
"Even when we examined only modest incremental reductions, we found the possibility of significant benefit."
At baseline, the patients’ average age was 66 years. The average HbA1c was 7%; systolic blood pressure 149 mmHg, and body mass index, 29.5 kg/m2. Most (92%) were taking only oral medications; the remainder was also taking insulin.
Some cardiovascular morbidity was already present in the group, including peripheral artery disease (0.5%), renal impairment (11%), neuropathy (51%), and retinopathy (7%). About half of the group (45%) had a family history of cardiovascular disease.
Dr. Heintjes divided the group according to the number of risk factors each patient exhibited. A quarter (24%) had just one elevated risk factor; 47% had two elevated risk factors, and 26% had elevations in all three risk factors.
A multivariable analysis allowed her to extrapolate that 796 cardiovascular events (heart attack, ischemic heart disease, stroke, and chronic heart failure) would occur if all of the patients were followed for 5 years.
If every patient in this population were able to correct each one of the risk factors to the national recommendations, she said, 687 events would occur – a 14% decrease. Correcting HbA1c and blood pressure accounted for this change, she said; changing BMI did nothing to increase the benefit.
Theoretically, she said, patients with the most risk factors would reap the greatest benefit. The 24% with one elevated risk factor would experience a 5% reduction in cardiovascular events, while those with all three elevated risk factors, upon correcting them, would see a 21% reduction.
Considering the group’s baseline measurements, correcting to national Dutch standards would mean an average HbA1c reduction of 0.8%, a 26-mmHg reduction in systolic blood pressure, and a weight loss of 16 kg (equivalent to a BMI decrease of 5.7 kg/m2). However, Dr. Heintjes said, it might not be realistic to expect such changes. Her second analysis explored the improvements that could arise from smaller changes: a 0.5% reduction in HbA1c, a 10-mmHg reduction in systolic blood pressure and a 10% reduction in total body weight (2.6 kg/m2 decrease in BMI).
"With this analysis, we saw in the overall population that 6% of the risk could be averted," she said. Among those in the subpopulation with three risk factors, applying the smaller changes could cut the number of events by 10%.
It’s not exactly clear how the results can change clinical practice, Dr. Heintjes acknowledged. "But this does allow us to understand how small changes can translate into bigger benefits for people with type 2 diabetes."
Dr. Heintjes reported having no conflicts of interest. Her employer, PHARMO, however, receives funding from numerous pharmaceutical companies, including Astra Zeneca, which sponsored the current study.
FROM THE ANNUAL MEETING OF THE EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES
Major Finding: Reducing HbA1c, blood pressure, and weight could avert up to 21% of cardiovascular events in patients with type 2 diabetes.
Data Source: A population-based observational study comprising 5,841 patients.
Disclosures: Dr. Heintjes reported having no conflicts of interest. Her employer, PHARMO, however, receives funding from numerous pharmaceutical companies, including Astra Zeneca, which sponsored the current study.
Temporary Staffing Common in HM, Study Reports
One in 10 hospitalists has worked locum tenens in the past year, according to a study of the practice released this week.
Locum Leaders, a locum tenens staffing agency in Alpharetta, Ga., put the study together this summer to define for the first time just how prevalent the practice of temporary staffing is and what motivates physicians to do the work. The report found that of hospitalists who work as locums tenens, 82% do it in addition to their full-time jobs and 11% do it as their full-time jobs.
Robert Harrington Jr., MD, SFHM, chief medical officer for Locum Leaders and an SHM board member, says the phenomenon allows some hospitalists to learn more about an institution before signing a long-term contract. It also affords other physicians flexibility, higher earning potential, or just the chance to "try something on for size before they buy."
"On the physician side, there are opportunities out there for you to not strain yourself immensely to increase your compensation, to travel to places you may not normally get to go, and to see how different programs are structured and operate," he says. "To see a more worldly view of hospital medicine."
For hospitals, even though locum physicians can cost more in salary, they can provide an opportunity for savings, as the hospital does not have to contribute to healthcare, pensions, or other costs. To wit, locum physicians can gross 30% to 40% more per year for the same number of shifts as a typical FTE hospitalist.
"They're all independent contractors," Dr. Harrington adds. "The increase in compensation that locum tenens physicians are able to demand, for the most part, comes from the difference between having a full-time employee versus an independent contractor."
One in 10 hospitalists has worked locum tenens in the past year, according to a study of the practice released this week.
Locum Leaders, a locum tenens staffing agency in Alpharetta, Ga., put the study together this summer to define for the first time just how prevalent the practice of temporary staffing is and what motivates physicians to do the work. The report found that of hospitalists who work as locums tenens, 82% do it in addition to their full-time jobs and 11% do it as their full-time jobs.
Robert Harrington Jr., MD, SFHM, chief medical officer for Locum Leaders and an SHM board member, says the phenomenon allows some hospitalists to learn more about an institution before signing a long-term contract. It also affords other physicians flexibility, higher earning potential, or just the chance to "try something on for size before they buy."
"On the physician side, there are opportunities out there for you to not strain yourself immensely to increase your compensation, to travel to places you may not normally get to go, and to see how different programs are structured and operate," he says. "To see a more worldly view of hospital medicine."
For hospitals, even though locum physicians can cost more in salary, they can provide an opportunity for savings, as the hospital does not have to contribute to healthcare, pensions, or other costs. To wit, locum physicians can gross 30% to 40% more per year for the same number of shifts as a typical FTE hospitalist.
"They're all independent contractors," Dr. Harrington adds. "The increase in compensation that locum tenens physicians are able to demand, for the most part, comes from the difference between having a full-time employee versus an independent contractor."
One in 10 hospitalists has worked locum tenens in the past year, according to a study of the practice released this week.
Locum Leaders, a locum tenens staffing agency in Alpharetta, Ga., put the study together this summer to define for the first time just how prevalent the practice of temporary staffing is and what motivates physicians to do the work. The report found that of hospitalists who work as locums tenens, 82% do it in addition to their full-time jobs and 11% do it as their full-time jobs.
Robert Harrington Jr., MD, SFHM, chief medical officer for Locum Leaders and an SHM board member, says the phenomenon allows some hospitalists to learn more about an institution before signing a long-term contract. It also affords other physicians flexibility, higher earning potential, or just the chance to "try something on for size before they buy."
"On the physician side, there are opportunities out there for you to not strain yourself immensely to increase your compensation, to travel to places you may not normally get to go, and to see how different programs are structured and operate," he says. "To see a more worldly view of hospital medicine."
For hospitals, even though locum physicians can cost more in salary, they can provide an opportunity for savings, as the hospital does not have to contribute to healthcare, pensions, or other costs. To wit, locum physicians can gross 30% to 40% more per year for the same number of shifts as a typical FTE hospitalist.
"They're all independent contractors," Dr. Harrington adds. "The increase in compensation that locum tenens physicians are able to demand, for the most part, comes from the difference between having a full-time employee versus an independent contractor."
The Appropriate Patient Census
What's the appropriate number of patients that an FTE hospitalist should see in one day? More than half of those surveyed on the-hospitalist.org believe they should see between 11 and 15 patients. According to two members of Team Hospitalist, 10 to 20 patients per day is a reasonable guideline.
"On average, 15 to 18 patients per day is a pretty easy-to-manage number," says Rachel George, MD, MBA, FHM, CPE, chief operating officer for Cogent HMG's west and north-central regions. But daily patient census depends on several factors, such as the types of patients admitted, the length of the doctor's shift, and the level of support from other staff on duty, she explains.
Readers were given one of five choices to respond with: "10 or fewer patients," "11-15," "16-20," "21-25," and "more than 25." Of the 421 responses, 51% felt that the average full-time hospitalist should see from 11 to 15 patients per day, followed by 35% who say they'd prefer to see 16 to 20 patients. Six percent voted for "10 or fewer." Only 4% of respondents said 20 or more patients a day was optimum.
"Honestly, I try not to get fixated on numbers," says Ken Simone, DO, SFHM, founder and president of Hospitalist and Practice Solutions in Veazie, Maine. As a consultant, he says that rather than trying to expect physicians to attend to a standard census, HM groups should focus on acuity of illness and quality of care, and let patient needs dictate the staff required. Dr. Simone also recalled working with some groups who have delegated one or more staff members to handle admitting and screening, so that hospitalists can concentrate on the patients already in beds.
What's the appropriate number of patients that an FTE hospitalist should see in one day? More than half of those surveyed on the-hospitalist.org believe they should see between 11 and 15 patients. According to two members of Team Hospitalist, 10 to 20 patients per day is a reasonable guideline.
"On average, 15 to 18 patients per day is a pretty easy-to-manage number," says Rachel George, MD, MBA, FHM, CPE, chief operating officer for Cogent HMG's west and north-central regions. But daily patient census depends on several factors, such as the types of patients admitted, the length of the doctor's shift, and the level of support from other staff on duty, she explains.
Readers were given one of five choices to respond with: "10 or fewer patients," "11-15," "16-20," "21-25," and "more than 25." Of the 421 responses, 51% felt that the average full-time hospitalist should see from 11 to 15 patients per day, followed by 35% who say they'd prefer to see 16 to 20 patients. Six percent voted for "10 or fewer." Only 4% of respondents said 20 or more patients a day was optimum.
"Honestly, I try not to get fixated on numbers," says Ken Simone, DO, SFHM, founder and president of Hospitalist and Practice Solutions in Veazie, Maine. As a consultant, he says that rather than trying to expect physicians to attend to a standard census, HM groups should focus on acuity of illness and quality of care, and let patient needs dictate the staff required. Dr. Simone also recalled working with some groups who have delegated one or more staff members to handle admitting and screening, so that hospitalists can concentrate on the patients already in beds.
What's the appropriate number of patients that an FTE hospitalist should see in one day? More than half of those surveyed on the-hospitalist.org believe they should see between 11 and 15 patients. According to two members of Team Hospitalist, 10 to 20 patients per day is a reasonable guideline.
"On average, 15 to 18 patients per day is a pretty easy-to-manage number," says Rachel George, MD, MBA, FHM, CPE, chief operating officer for Cogent HMG's west and north-central regions. But daily patient census depends on several factors, such as the types of patients admitted, the length of the doctor's shift, and the level of support from other staff on duty, she explains.
Readers were given one of five choices to respond with: "10 or fewer patients," "11-15," "16-20," "21-25," and "more than 25." Of the 421 responses, 51% felt that the average full-time hospitalist should see from 11 to 15 patients per day, followed by 35% who say they'd prefer to see 16 to 20 patients. Six percent voted for "10 or fewer." Only 4% of respondents said 20 or more patients a day was optimum.
"Honestly, I try not to get fixated on numbers," says Ken Simone, DO, SFHM, founder and president of Hospitalist and Practice Solutions in Veazie, Maine. As a consultant, he says that rather than trying to expect physicians to attend to a standard census, HM groups should focus on acuity of illness and quality of care, and let patient needs dictate the staff required. Dr. Simone also recalled working with some groups who have delegated one or more staff members to handle admitting and screening, so that hospitalists can concentrate on the patients already in beds.
By the Numbers: $4,000
According to a new study in American Economic Journal: Applied Economics by MIT economist Joseph Doyle, a $4,000 increase in per-patient hospital expenditures equates to a 1.4% decrease in mortality rates. Doyle studied 37,000 hospitalized patients in Florida who entered through the ED from 1996 to 2003. However, he focused on those visiting from other states in order to identify variation resulting from the level of care itself, not the prior health of the patients. The greater expense—and benefits—of care in the higher-cost hospital appeared to come from the broader application of ICU tools and greater complement of medical personnel, he notes.
“There are smart ways to spend money and ineffective ways to spend money,” he says, “and we’re still trying to figure out which are which, as much as possible.”
According to a new study in American Economic Journal: Applied Economics by MIT economist Joseph Doyle, a $4,000 increase in per-patient hospital expenditures equates to a 1.4% decrease in mortality rates. Doyle studied 37,000 hospitalized patients in Florida who entered through the ED from 1996 to 2003. However, he focused on those visiting from other states in order to identify variation resulting from the level of care itself, not the prior health of the patients. The greater expense—and benefits—of care in the higher-cost hospital appeared to come from the broader application of ICU tools and greater complement of medical personnel, he notes.
“There are smart ways to spend money and ineffective ways to spend money,” he says, “and we’re still trying to figure out which are which, as much as possible.”
According to a new study in American Economic Journal: Applied Economics by MIT economist Joseph Doyle, a $4,000 increase in per-patient hospital expenditures equates to a 1.4% decrease in mortality rates. Doyle studied 37,000 hospitalized patients in Florida who entered through the ED from 1996 to 2003. However, he focused on those visiting from other states in order to identify variation resulting from the level of care itself, not the prior health of the patients. The greater expense—and benefits—of care in the higher-cost hospital appeared to come from the broader application of ICU tools and greater complement of medical personnel, he notes.
“There are smart ways to spend money and ineffective ways to spend money,” he says, “and we’re still trying to figure out which are which, as much as possible.”
Transferring “Boarders” Could Save Millions
A pilot project that transferred “boarded” patients from one hospital’s ED to an inpatient bed at another nearby hospital in the same health system suggests that the concept could save hospitals millions.
“Improvement in Emergency Department Treatment Capacity: A Health System Integration Approach” was the subject of an oral presentation at HM11 in Dallas. Lead researcher Diego Martinez-Vasquez, MD, MPH, FACP, CPE, medical director for clinical resource utilization at Franklin Square Hospital Center in Baltimore, conducted the research in the University of Maryland medical system.
In the project, 265 patients who consented were transferred 1.3 miles to a sister hospital. Without “boarders”—admitted patients held in the ED—Dr. Martinez-Vasquez’s team found that the referring hospital could have regained enough capacity for an additional 2.9 patients per day. The project also showed median net revenue of $520,000 for the referring hospital and $1.9 million for the accepting hospital.
“The hospitalist group at the receiving hospital was the instrument that facilitated this program,” Dr. Martinez-Vasquez says. “But really what kept my attention was that healthcare systems sometimes don’t use resources effectively. So when I looked at the problem that this particular hospital was having regarding increased boarding time and decreased treatment capacity, I said, ‘Well, one way to resolve this issue is to develop a process that connects two system hospitals and their bed resources.’ ”
A pilot project that transferred “boarded” patients from one hospital’s ED to an inpatient bed at another nearby hospital in the same health system suggests that the concept could save hospitals millions.
“Improvement in Emergency Department Treatment Capacity: A Health System Integration Approach” was the subject of an oral presentation at HM11 in Dallas. Lead researcher Diego Martinez-Vasquez, MD, MPH, FACP, CPE, medical director for clinical resource utilization at Franklin Square Hospital Center in Baltimore, conducted the research in the University of Maryland medical system.
In the project, 265 patients who consented were transferred 1.3 miles to a sister hospital. Without “boarders”—admitted patients held in the ED—Dr. Martinez-Vasquez’s team found that the referring hospital could have regained enough capacity for an additional 2.9 patients per day. The project also showed median net revenue of $520,000 for the referring hospital and $1.9 million for the accepting hospital.
“The hospitalist group at the receiving hospital was the instrument that facilitated this program,” Dr. Martinez-Vasquez says. “But really what kept my attention was that healthcare systems sometimes don’t use resources effectively. So when I looked at the problem that this particular hospital was having regarding increased boarding time and decreased treatment capacity, I said, ‘Well, one way to resolve this issue is to develop a process that connects two system hospitals and their bed resources.’ ”
A pilot project that transferred “boarded” patients from one hospital’s ED to an inpatient bed at another nearby hospital in the same health system suggests that the concept could save hospitals millions.
“Improvement in Emergency Department Treatment Capacity: A Health System Integration Approach” was the subject of an oral presentation at HM11 in Dallas. Lead researcher Diego Martinez-Vasquez, MD, MPH, FACP, CPE, medical director for clinical resource utilization at Franklin Square Hospital Center in Baltimore, conducted the research in the University of Maryland medical system.
In the project, 265 patients who consented were transferred 1.3 miles to a sister hospital. Without “boarders”—admitted patients held in the ED—Dr. Martinez-Vasquez’s team found that the referring hospital could have regained enough capacity for an additional 2.9 patients per day. The project also showed median net revenue of $520,000 for the referring hospital and $1.9 million for the accepting hospital.
“The hospitalist group at the receiving hospital was the instrument that facilitated this program,” Dr. Martinez-Vasquez says. “But really what kept my attention was that healthcare systems sometimes don’t use resources effectively. So when I looked at the problem that this particular hospital was having regarding increased boarding time and decreased treatment capacity, I said, ‘Well, one way to resolve this issue is to develop a process that connects two system hospitals and their bed resources.’ ”
High-Performing Hospitals Invest in QI Infrastructure
A new study evaluating outcomes for hospitals participating in the American Heart Association’s Get with the Guidelines program found no correlation between high performance on adhering to measures and care standards for acute myocardial infarction and for heart failure despite overlap between the sets of care processes (J Am Coll Cardio. 2011;58:637-644).
A total of 400,000 heart patients were studied, and 283 participating hospitals were stratified into thirds based on their adherence to core quality measures for each disease, with the upper third labeled superior in performance. Lead author Tracy Wang, MD, MHS, MSc, of the Duke Clinical Research Institute in Durham, N.C., and colleagues found that superior performance for only one of the two diseases led to such end-result outcomes as in-hospital mortality that were no better than for hospitals that were not high performers for either condition. But hospitals with superior performance for both conditions had lower in-hospital mortality rates.
“Perhaps quality is more than just following checklists,” Dr. Wang says. “There’s something special about these high-performing hospitals across the board, with better QI, perhaps a little more investment in infrastructure for quality.”
This result, Dr. Wang says, should give ammunition for hospitalists and other physicians to go to their hospital administrators to request more investment in quality improvement overall, not just for specific conditions.
A new study evaluating outcomes for hospitals participating in the American Heart Association’s Get with the Guidelines program found no correlation between high performance on adhering to measures and care standards for acute myocardial infarction and for heart failure despite overlap between the sets of care processes (J Am Coll Cardio. 2011;58:637-644).
A total of 400,000 heart patients were studied, and 283 participating hospitals were stratified into thirds based on their adherence to core quality measures for each disease, with the upper third labeled superior in performance. Lead author Tracy Wang, MD, MHS, MSc, of the Duke Clinical Research Institute in Durham, N.C., and colleagues found that superior performance for only one of the two diseases led to such end-result outcomes as in-hospital mortality that were no better than for hospitals that were not high performers for either condition. But hospitals with superior performance for both conditions had lower in-hospital mortality rates.
“Perhaps quality is more than just following checklists,” Dr. Wang says. “There’s something special about these high-performing hospitals across the board, with better QI, perhaps a little more investment in infrastructure for quality.”
This result, Dr. Wang says, should give ammunition for hospitalists and other physicians to go to their hospital administrators to request more investment in quality improvement overall, not just for specific conditions.
A new study evaluating outcomes for hospitals participating in the American Heart Association’s Get with the Guidelines program found no correlation between high performance on adhering to measures and care standards for acute myocardial infarction and for heart failure despite overlap between the sets of care processes (J Am Coll Cardio. 2011;58:637-644).
A total of 400,000 heart patients were studied, and 283 participating hospitals were stratified into thirds based on their adherence to core quality measures for each disease, with the upper third labeled superior in performance. Lead author Tracy Wang, MD, MHS, MSc, of the Duke Clinical Research Institute in Durham, N.C., and colleagues found that superior performance for only one of the two diseases led to such end-result outcomes as in-hospital mortality that were no better than for hospitals that were not high performers for either condition. But hospitals with superior performance for both conditions had lower in-hospital mortality rates.
“Perhaps quality is more than just following checklists,” Dr. Wang says. “There’s something special about these high-performing hospitals across the board, with better QI, perhaps a little more investment in infrastructure for quality.”
This result, Dr. Wang says, should give ammunition for hospitalists and other physicians to go to their hospital administrators to request more investment in quality improvement overall, not just for specific conditions.
Joint Commission Launches Certification for Hospital Palliative Care
A new Joint Commission program offering advanced certification for hospital-based palliative-care services is accepting applications and conducting daylong surveys through the end of this month. As with the Joint Commission’s reviews of other specialty services (e.g. primary stroke centers), certification is narrower in scope, with service-specific evaluation of care and outcomes, than a full accreditation survey—which is an organizationwide evaluation of core processes and functions.
Advanced certification in palliative care is voluntary for the steadily growing number of acute-care hospitals offering palliative-care services (1,568, according to the latest count by the American Hospital Association), but the hospital seeking it must be accredited by the Joint Commission.1 Certification is intended for formal, defined, inpatient palliative care, whether dedicated units or consultation services, with the ability to direct clinical management of patients.
The core palliative-care team includes “licensed independent practitioners” (typically physicians), registered nurses, chaplains, and social workers.2 The service should follow palliative-care guidelines and evidence-based practice, and it must collect quality data on four performance measures—two of them clinical—and use these data to improve performance.
According to Michelle Sacco, the Joint Commission’s executive director for palliative care, evidence-based practice includes ensuring appropriate transitions to other community resources, such as hospices. She thinks the program is perfect for hospitalists, as HM increasingly is participating in palliative care in their hospitals. “This is also an opportunity to change the mindset that palliative care is for the end-stage only,” Sacco says.
Two-year certification costs $9,655, including the onsite review. For more information, visit the Joint Commission website (www.jointcommission.org/certification) or the Center to Advance Palliative Care’s site (www.capc.org).
References
- Palliative care in hospitals continues rapid growth for 10th straight year, according to latest analysis. Center to Advance Palliative Care website. Available at: www.capc.org/news-and-events/releases/07-14-11. Accessed Aug. 30, 2011.
- The National Consensus Project’s Clinical Practice Guidelines for Quality Palliative Care. The National Consensus Project website. Available at: www.nationalconsensusproject.org/. Accessed Aug. 31, 2011.
A new Joint Commission program offering advanced certification for hospital-based palliative-care services is accepting applications and conducting daylong surveys through the end of this month. As with the Joint Commission’s reviews of other specialty services (e.g. primary stroke centers), certification is narrower in scope, with service-specific evaluation of care and outcomes, than a full accreditation survey—which is an organizationwide evaluation of core processes and functions.
Advanced certification in palliative care is voluntary for the steadily growing number of acute-care hospitals offering palliative-care services (1,568, according to the latest count by the American Hospital Association), but the hospital seeking it must be accredited by the Joint Commission.1 Certification is intended for formal, defined, inpatient palliative care, whether dedicated units or consultation services, with the ability to direct clinical management of patients.
The core palliative-care team includes “licensed independent practitioners” (typically physicians), registered nurses, chaplains, and social workers.2 The service should follow palliative-care guidelines and evidence-based practice, and it must collect quality data on four performance measures—two of them clinical—and use these data to improve performance.
According to Michelle Sacco, the Joint Commission’s executive director for palliative care, evidence-based practice includes ensuring appropriate transitions to other community resources, such as hospices. She thinks the program is perfect for hospitalists, as HM increasingly is participating in palliative care in their hospitals. “This is also an opportunity to change the mindset that palliative care is for the end-stage only,” Sacco says.
Two-year certification costs $9,655, including the onsite review. For more information, visit the Joint Commission website (www.jointcommission.org/certification) or the Center to Advance Palliative Care’s site (www.capc.org).
References
- Palliative care in hospitals continues rapid growth for 10th straight year, according to latest analysis. Center to Advance Palliative Care website. Available at: www.capc.org/news-and-events/releases/07-14-11. Accessed Aug. 30, 2011.
- The National Consensus Project’s Clinical Practice Guidelines for Quality Palliative Care. The National Consensus Project website. Available at: www.nationalconsensusproject.org/. Accessed Aug. 31, 2011.
A new Joint Commission program offering advanced certification for hospital-based palliative-care services is accepting applications and conducting daylong surveys through the end of this month. As with the Joint Commission’s reviews of other specialty services (e.g. primary stroke centers), certification is narrower in scope, with service-specific evaluation of care and outcomes, than a full accreditation survey—which is an organizationwide evaluation of core processes and functions.
Advanced certification in palliative care is voluntary for the steadily growing number of acute-care hospitals offering palliative-care services (1,568, according to the latest count by the American Hospital Association), but the hospital seeking it must be accredited by the Joint Commission.1 Certification is intended for formal, defined, inpatient palliative care, whether dedicated units or consultation services, with the ability to direct clinical management of patients.
The core palliative-care team includes “licensed independent practitioners” (typically physicians), registered nurses, chaplains, and social workers.2 The service should follow palliative-care guidelines and evidence-based practice, and it must collect quality data on four performance measures—two of them clinical—and use these data to improve performance.
According to Michelle Sacco, the Joint Commission’s executive director for palliative care, evidence-based practice includes ensuring appropriate transitions to other community resources, such as hospices. She thinks the program is perfect for hospitalists, as HM increasingly is participating in palliative care in their hospitals. “This is also an opportunity to change the mindset that palliative care is for the end-stage only,” Sacco says.
Two-year certification costs $9,655, including the onsite review. For more information, visit the Joint Commission website (www.jointcommission.org/certification) or the Center to Advance Palliative Care’s site (www.capc.org).
References
- Palliative care in hospitals continues rapid growth for 10th straight year, according to latest analysis. Center to Advance Palliative Care website. Available at: www.capc.org/news-and-events/releases/07-14-11. Accessed Aug. 30, 2011.
- The National Consensus Project’s Clinical Practice Guidelines for Quality Palliative Care. The National Consensus Project website. Available at: www.nationalconsensusproject.org/. Accessed Aug. 31, 2011.
PET Scans Key to Less Radiation for Hodgkin's Lymphoma
MIAMI BEACH – Patients with Hodgkin’s lymphoma may be spared additional radiotherapy following chemotherapy if they have a negative positron-emission tomography result, investigators from the German Hodgkin Study Group reported.
The negative predictive value for FDG (18fluorodeoxyglucose)–PET at 1 year was 94%, said Dr. Rolf P. Mueller of the University of Cologne (Germany). Among patients who had residual tumors measuring 2.5 cm or greater in diameter following chemotherapy, only 4% of those who were negative for residual disease on FDG-PET scans relapsed or required additional radiotherapy, compared with 11% of FDG-PET–positive patients.
"Thus, only those advanced-stage Hodgkin lymphoma patients with residual disease who are PET-positive patients might need additional radiotherapy," Dr. Mueller said at the annual meeting of the American Society of Radiation Oncology (ASTRO).
The investigators also found a significant difference in time-to-progression favoring PET-negative patients (P =.008) with Hodgkin’s lymphoma, also known as Hodgkin’s disease.
The percentage of patients who received radiation in this clinical trial, designated GHSG (German Hodgkin Study Group) HD-15, was 11%, compared with 70% of patients in the group’s GHSG-9 trial, Mueller noted. GHSG-15 studied the role of FDG-PET for evaluating residual disease and relapse risk among patients with advanced-stage Hodgkin’s lymphoma who had undergone six to eight cycles of chemotherapy with the BEACOPP regimen (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) (J. Clin. Oncol. 2003;21:1734-9).
Early results were published in 2008 (Blood 2008;112: 3989-94). In the current report, Mueller presented data on a larger cohort.
All patients with a partial response or better and a residual mass measuring 2.5 cm or greater received FDG-PET scans. Of the 728 patients with residual disease following BEACOPP, 540 (74.2%) were PET negative, and 188 were PET positive. Mueller presented data on 701 patients who had at least 1 year of follow-up.
At 1 year, 96% (522) of PET-negative patients had neither progression nor relapse, compared with 11% of those who were PET positive. Of the PET-negative patients, 23 experienced disease progression (eight in the residual mass, six with new disease outside of the mass, and nine with progression/relapse in both areas). An additional eight PET-negative patients required additional radiotherapy.
The study was funded by the member centers of the GSHG. Dr. Mueller had no conflict of interest disclosures.
MIAMI BEACH – Patients with Hodgkin’s lymphoma may be spared additional radiotherapy following chemotherapy if they have a negative positron-emission tomography result, investigators from the German Hodgkin Study Group reported.
The negative predictive value for FDG (18fluorodeoxyglucose)–PET at 1 year was 94%, said Dr. Rolf P. Mueller of the University of Cologne (Germany). Among patients who had residual tumors measuring 2.5 cm or greater in diameter following chemotherapy, only 4% of those who were negative for residual disease on FDG-PET scans relapsed or required additional radiotherapy, compared with 11% of FDG-PET–positive patients.
"Thus, only those advanced-stage Hodgkin lymphoma patients with residual disease who are PET-positive patients might need additional radiotherapy," Dr. Mueller said at the annual meeting of the American Society of Radiation Oncology (ASTRO).
The investigators also found a significant difference in time-to-progression favoring PET-negative patients (P =.008) with Hodgkin’s lymphoma, also known as Hodgkin’s disease.
The percentage of patients who received radiation in this clinical trial, designated GHSG (German Hodgkin Study Group) HD-15, was 11%, compared with 70% of patients in the group’s GHSG-9 trial, Mueller noted. GHSG-15 studied the role of FDG-PET for evaluating residual disease and relapse risk among patients with advanced-stage Hodgkin’s lymphoma who had undergone six to eight cycles of chemotherapy with the BEACOPP regimen (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) (J. Clin. Oncol. 2003;21:1734-9).
Early results were published in 2008 (Blood 2008;112: 3989-94). In the current report, Mueller presented data on a larger cohort.
All patients with a partial response or better and a residual mass measuring 2.5 cm or greater received FDG-PET scans. Of the 728 patients with residual disease following BEACOPP, 540 (74.2%) were PET negative, and 188 were PET positive. Mueller presented data on 701 patients who had at least 1 year of follow-up.
At 1 year, 96% (522) of PET-negative patients had neither progression nor relapse, compared with 11% of those who were PET positive. Of the PET-negative patients, 23 experienced disease progression (eight in the residual mass, six with new disease outside of the mass, and nine with progression/relapse in both areas). An additional eight PET-negative patients required additional radiotherapy.
The study was funded by the member centers of the GSHG. Dr. Mueller had no conflict of interest disclosures.
MIAMI BEACH – Patients with Hodgkin’s lymphoma may be spared additional radiotherapy following chemotherapy if they have a negative positron-emission tomography result, investigators from the German Hodgkin Study Group reported.
The negative predictive value for FDG (18fluorodeoxyglucose)–PET at 1 year was 94%, said Dr. Rolf P. Mueller of the University of Cologne (Germany). Among patients who had residual tumors measuring 2.5 cm or greater in diameter following chemotherapy, only 4% of those who were negative for residual disease on FDG-PET scans relapsed or required additional radiotherapy, compared with 11% of FDG-PET–positive patients.
"Thus, only those advanced-stage Hodgkin lymphoma patients with residual disease who are PET-positive patients might need additional radiotherapy," Dr. Mueller said at the annual meeting of the American Society of Radiation Oncology (ASTRO).
The investigators also found a significant difference in time-to-progression favoring PET-negative patients (P =.008) with Hodgkin’s lymphoma, also known as Hodgkin’s disease.
The percentage of patients who received radiation in this clinical trial, designated GHSG (German Hodgkin Study Group) HD-15, was 11%, compared with 70% of patients in the group’s GHSG-9 trial, Mueller noted. GHSG-15 studied the role of FDG-PET for evaluating residual disease and relapse risk among patients with advanced-stage Hodgkin’s lymphoma who had undergone six to eight cycles of chemotherapy with the BEACOPP regimen (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) (J. Clin. Oncol. 2003;21:1734-9).
Early results were published in 2008 (Blood 2008;112: 3989-94). In the current report, Mueller presented data on a larger cohort.
All patients with a partial response or better and a residual mass measuring 2.5 cm or greater received FDG-PET scans. Of the 728 patients with residual disease following BEACOPP, 540 (74.2%) were PET negative, and 188 were PET positive. Mueller presented data on 701 patients who had at least 1 year of follow-up.
At 1 year, 96% (522) of PET-negative patients had neither progression nor relapse, compared with 11% of those who were PET positive. Of the PET-negative patients, 23 experienced disease progression (eight in the residual mass, six with new disease outside of the mass, and nine with progression/relapse in both areas). An additional eight PET-negative patients required additional radiotherapy.
The study was funded by the member centers of the GSHG. Dr. Mueller had no conflict of interest disclosures.
FROM THE ANNUAL MEETING OF THE AMERICAN SOCIETY FOR RADIATION ONCOLOGY
Major Finding: FDG-PET scans following chemotherapy in patients with advanced-stage Hodgkin’s lymphoma have a negative predictive value of 94%.
Data Source: The prospective GHSG HD-15 trial involving 701 patients.
Disclosures: The study was funded by the GSHG. Dr. Mueller had no conflict of interest disclosures.
Academic Hospitalists Gear Up for Learning
The challenges of academic HM are different from other sectors of the specialty. Academic hospitalists, division chiefs, and administrators at academic teaching hospitals contend with the pressure of receiving grants, presenting at grand rounds, and reserving time for research and educational projects.
While it can be overwhelming, especially for academic hospitalists early in their careers, the Academic Hospitalist Academy helps untangle those challenges and turn them into long-term professional opportunities. Hosted jointly by SHM, the Society of General Internal Medicine (SGIM), and the Association of Chiefs and Leaders of General Internal Medicine (ACLGIM), the academy is a three-day course dedicated to education, scholarship, and professional success for academic hospitalists.
In addition to helping them become better hospitalists, Academic Hospitalist Academy uses didactic sessions, small-group exercises, and other interactive techniques to help academic hospitalists become better teachers, create and publish scholarly work, and get first in line for promotions.
Now in its third year, Academic Hospitalist Academy is consistently met with rave reviews from attendees. According to evaluations from the 2010 academy, attendees unanimously felt the course was worth their time and money; 99% said they would recommend it to a colleague.
The challenges of academic HM are different from other sectors of the specialty. Academic hospitalists, division chiefs, and administrators at academic teaching hospitals contend with the pressure of receiving grants, presenting at grand rounds, and reserving time for research and educational projects.
While it can be overwhelming, especially for academic hospitalists early in their careers, the Academic Hospitalist Academy helps untangle those challenges and turn them into long-term professional opportunities. Hosted jointly by SHM, the Society of General Internal Medicine (SGIM), and the Association of Chiefs and Leaders of General Internal Medicine (ACLGIM), the academy is a three-day course dedicated to education, scholarship, and professional success for academic hospitalists.
In addition to helping them become better hospitalists, Academic Hospitalist Academy uses didactic sessions, small-group exercises, and other interactive techniques to help academic hospitalists become better teachers, create and publish scholarly work, and get first in line for promotions.
Now in its third year, Academic Hospitalist Academy is consistently met with rave reviews from attendees. According to evaluations from the 2010 academy, attendees unanimously felt the course was worth their time and money; 99% said they would recommend it to a colleague.
The challenges of academic HM are different from other sectors of the specialty. Academic hospitalists, division chiefs, and administrators at academic teaching hospitals contend with the pressure of receiving grants, presenting at grand rounds, and reserving time for research and educational projects.
While it can be overwhelming, especially for academic hospitalists early in their careers, the Academic Hospitalist Academy helps untangle those challenges and turn them into long-term professional opportunities. Hosted jointly by SHM, the Society of General Internal Medicine (SGIM), and the Association of Chiefs and Leaders of General Internal Medicine (ACLGIM), the academy is a three-day course dedicated to education, scholarship, and professional success for academic hospitalists.
In addition to helping them become better hospitalists, Academic Hospitalist Academy uses didactic sessions, small-group exercises, and other interactive techniques to help academic hospitalists become better teachers, create and publish scholarly work, and get first in line for promotions.
Now in its third year, Academic Hospitalist Academy is consistently met with rave reviews from attendees. According to evaluations from the 2010 academy, attendees unanimously felt the course was worth their time and money; 99% said they would recommend it to a colleague.